Vagn Walfrid Ekman. 1874-1954

Dmd052597 1867..1874

The primary objective of this study was to determine the in vivo absorption properties of valacyclovir, including the potential for saturable proton-coupled oligopeptide transporter 1 (PepT1)-mediated intestinal uptake, after escalating oral doses of prodrug within the clinical dose range. A secondary aim was to characterize the role of PepT1 on the tissue distribution of its active metabolite,...

Op-cbio150045 1872..1874

Summary: The association of organisms to their environments is a key issue in exploring biodiversity patterns. This knowledge has traditionally been scattered, but textual descriptions of taxa and their habitats are now being consolidated in centralized resources. However, structured annotations are needed to facilitate large-scale analyses. Therefore, we developed ENVIRONMENTS, a fast dictiona...

Edward Clark Streeter, 1874-1947

Dev105791 1864..1874

MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression that play important roles in nervous system development and physiology. However, our understanding of the strategies by which miRNAs control synapse development is limited.We find that the highly conserved miRNA miR-8 regulates the morphology of presynaptic arbors at the Drosophila neuromuscular junction (NMJ) through a p...

Solar Irradiance since 1874 Revisited

We reconstruct the solar irradiance since 1874 employing an evolved version of previously published models and improved sunspot and facular data. A good correlation between reconstructed irradiance and Earth’s global air temperature on time scales longer than the solar cycle is obtained and, in contrast to many earlier models, solar irradiance does not on average lag behind global temperature p...